SINTESIS DAN UJI AKTIVITAS TOKSISITAS SENYAWA ANALOG KALKON TURUNAN 2’-METOKSIASETOFENON

Abstract

Chalcone is one of secondary metabolites from flavonoids group that have been reported to posses many biological activities such as antimicrobial, antitumor, antioxidant, anti-inflammatory, antimalari and anticancer. Chalcone generally can be synthesized by Claisen-Schmidt condensation from aldehide and ketone aromatic using acid or base catalyst. Three hydroxy analogues chalcone i.e., (E)-3-(2-hidroksifenil)-1- (2’-metoksifenil)prop-2-en-1-on, (E)-3-(3-hidroksifenil)-1-(2’-metoksifenil)prop-2-en- 1-on and (E)-3-(4-hidroksifenil)-1-(2’-metoksifenil)prop-2-en-1-on have been synthesized under microwave irradiation by using pottasium hydroxide as catalyst. The structure of those compounds were characterized based on the interpretation of spectroscopic data included UV, FTIR, 1H-NMR and HRMS. Their toxicity activity were determined by using the Brine Shrimp Lethality Test method againts larvae of Artemia salina Leach and showed high activity with LC50 value was 66,59 μg/mL, 107,45 μg/mL and 449,44 μg/mL, respectivel. It indicated that chalcone analogues were potential as anticancer