Abstract:
Curcumin is one of secondary metabolites of phenolic group of which has been known to have various biological activities such as antimicrobe, anticancer, antioxidant, antitumor, and anti-inflammatory. Curcumin becomes a model for target molecules because of its various structures. In this research, curcumin analog compound of cyclohexanones derivates were synthesized by microwave irradiation method using base catalyst (NaOH). The purity of all compounds have been tested using TLC, melting point test, and analytical HPLC. They were them characterized using UV, FTIR, 1H-NMR, and MS spectroscopy. The yield of sinthesized compound was 36.0% for (2E,6E)-2,6 bis(4-methylbenzylidene)cyclohexanone (DC1) and 37.5% for (2E,6E)-2,6 bis(4-isopropylbenzylidene)cyclohexanone (DC2). Toxicity test of these novel compounds was determined by Brine shrimp Lethality Test (BSLT) method against Artemia salina Leach larva. The result showed that their LC50 were higher than 200 μg/mL. Toxicity test result of all compounds showed that toxicity activity of DC1 and DC2was low.
