POLA RESISTENSI BAKTERI DARI SPUTUM PENDERITA PENYAKIT PARU OBSTRUKTIF KRONIK (PPOK) EKSASERBASI BAGIAN PARU RSUD ARIFIN ACHMAD PEKANBARU

Abstract

Abstract Chronic obstructive pulmonary disease (COPD) is a progressive airway obstruction, irreversible and often experience exacerbations because of bacterial colonization has occurred. Management of COPD exacerbations are caused by bacteria still rely on antibiotics to decrease mortality and morbidity rate. The purpose of this study were to find out the pattern of the bacteria that cause COPD exacerbation and it sensitivity to various antibiotics. Samples were sputum of patients with COPD exacerbation Lung Poly and inpatients at RSUD Arifin Achmad. Of the 30 sputum samples obtained 23 isolates of pathogenic bacteria and 9 non- pathogenic bacterial isolates, 56.52% were Gram-positive and 43.47% were Gram-negative bacteria. The pattern of bacterial isolates obtained were 12 coagulase negative Staphylococcus (37.50%), 1 isolate of Streptococcus pyogenes (3.12%), 6 isolates of Pseudomonas aeruginosa (18.75%), 3 isolates of Klebsiella spp (9.37%), 1 isolate of Escherichia coli (3.12%) and 9 isolates of Streptococcus viridians (28.12%). The sensitivity test results showed Gram-positive bacteria have the highest sensitivity to ciprofloxacin (30.77%), levofloxacin (23.08%), cefotaxime and ertitromisin (7.69%) while the highest resistance to cefixime, ceftriaxone, gentamicin, and amox-klav meropenem (100%). For Gram-negative bacteria have the highest sensitivity was found to ciprofloxacin, levofloxacin, and meropenem (40%) and cefepime (20%) while the highest resistance to cefixime, cefotaxime, ceftriaxone, erythromycin, gentamicin and amox-klav