Gambaran Inflamasi Hepar Pada Tikus Yang Diberi Diet Aterogenik

Abstract

Atherogenics diet had increase inflammation, especially in vascular system. This research had an aim to is to evaluate whether inflammation also happened in hepar histopathology of Wistar rat which fed by atherogenic diet for 5, 8 and 12 weeks. Methods: By using rat as animal experiment, fed by cholesterol from egg yolk (2%), goat fat(5%), cholate acid (0,2%) mixed in standard food, and given 20 g/day/each rat . Vitamin D3 for initial dosage (700.000 IU/kg) was given in the first day, and repeated every four weeks 300.000 IU/kg by using sondage. There are 3 groups of rats; 8 weeks group (P1), 12 weeks group (P2), and control group (P0). For control group, the animal only fed by standard food without giving vitamin D3. Histopathology evaluation based on Histological activity by Metavir system, which grade into none, mild, moderate and severe. Results: For control group, there are 60% samples with mild activity score and 40% with moderate activity score. For 8 weeks group, there are 67% samples with moderate activity score and 33% with mild activity score. For 12 weeks group, all of samples with mild activity score.