Abstract:
Curcumin is a colouring agent of Curcuma longa L. Beside the use of it as natural colourant, curcumin has biological activities such as antibacterial. In this research, curcumin analog compound of (3E,5E)-3,5-bis(4-hydroxybenzylidene)piperidin-4-one was synthesized with an acid catalyst (SOCl2) and the rendement obtained was 53.49 %. The purity of the compound has been tested using TLC, melting point test, and analytical HPLC. The identification of curcumin analogues was done using UV, IR,
MS, 1 H NMR, and
13 C NMR. Antibacterial activity of the compound was identified by
using disc diffusion method. The result showed that this analog of curcumin is inactive
as an antibacterial agent.
