Abstract:
Chalcone is one of secondary metabolites included into the class of flavonoids that are
known to have biological activities. Chalcone can be used as an intermediate for
synthesizing heterocyclic compounds, such as flavones, flavanols, flavanones, and others that also have biological activities. Chalcone generally can be synthesis by Claisen-Schmidth condensation from aldehide and ketone aromatic using acid or base
catalyst. Chalcone compound 3,4’- dimetoxy acetophenone derivative was synthesis using the microwave with a base catalyst (KOH). The yield obtained from each of
chalcone analogs are (E)-1-(3,4-dimetoxy phenil)-3-(4-hidroxy phenil)prop-2-en-1-one
(M1) with value 36,5%, (E)-1-(3,4-dimetoxy phenil)-3-(3-hidroxy phenil)prop-2-en-1-
one (M2) with value 93,3% and (E)-1-(3,4-dimetoxy phenil)-3-(2-hidroxy phenil)prop-
2-en-1-one (M3) with value 57,3%. The characterization of all compounds have been
tested using UV-Vis. IR, 1H NMR and MS. The toxicity test was done by Brine Shrimp Lethality Test (BSLT) method using Artemia salina Leach. The compound of M1, M2
and M3 showed that value LC50 in sequence are 41,687 μg/mL; 253,513 μg/mL and 29,512 μg/mL. Two analogs of chalcone compounds are positive as anticancer proved by LC50 values <200 μg/mL and one compound is negative as anticancer proved by LC50 value > 200 μg/mL
