Abstract:
Curcumin is one of secondary metabolites included into the class of group fenolic which was known to have biological activity such as anticancer, antioxidant, antidiabetic, and anti-inflammatory. Therefore , curcumin becomes model of target compounds that have various structure. In this research, curcumin analog coumponds of 1- methyl-4- piperidone derivative were synthesized using microwave irradiation with a base catalyst (NaOH). The rendement obtained from each of curcumin analogs are (3E,5E)-3,5-bis (2-chlorobenzilidyn)-1-methylpiperidyn-4-one (1) with value 38,86 %, (3E,5E)-3,5-bis (4-chlorobenzilidyn)-1-methylpiperidyn-4-one (2) with value 65,60 % dan (3E,5E)-3,5-bis (3-bromobenzilidyn)-1-methylpiperidyn-4-one (3) with value 19,73%. The purity of all compounds has been tested using TLC, melting point test, and analytical HPLC. The identification of curcumin analog coumponds was analysed using UV, IR, 1H NMR and MS. The toxicity test done by Brine Shrimpt Lethality Test (BSLT) method to artemia salina Leach larva showed that LC50 < 200 μg/mL. The result toxicity test to all of compounds showed that the coumpond(1) is the most toxic compared to (2) and (3).
