Sintesis Calkon Piridin dan Turunannya dari 2-Asetilpiridin dengan Metoksibenzaldehid serta Uji Aktivitasnya sebagai Antioksidan

Abstract

Chalcone are known to exhibit various biological activities such as antioxidant, antimalaria, anticancer, anti-inflammatory and antimicrobial. Chalcone as antioxidant can neutralize free radicals by donating an electron to the reactive species. Two analogous chalcone have been synthesized from 2-acetyl pyridine and methoxybenzaldehyd derivates with claisen schmidt condensation using base catalyst KOH. The compounds of synthesized produce are 2,6-bis(3,4-dimethoxyphenyl)- 4-hydroxy-4-(pyridine-2-yl)cyclohexane- 1,3-diil)bis(pyridine-2-ilmetanon) (SC1) and (E)-3-(2,4,5-trimethoxy phenyl) -1-(pyridine-2-yl) prop-2-en-1-one (SC2). The productc of synthesis then characterized using UV, IR, 1H-NMR, 13C-NMR and mass spectroscopy. Antioxidant activity was tested using DPPH method and the standard used is ascorbic acid. Assay results of the two compounds showed very weak antioxidant activity because the IC50 is more than 250 ppm