UJI TOKSISITAS EKSTRAK METANOL DAUN MANGGA MEMPELAM (Mangifera laurina BI.) DENGAN METODE BRINE SHRIMP LETHALITY TEST (BSLT)

Abstract

Mempelam or Mangifera laurina BI. known as semi-wild Sumatran mango which has a wide therapeutic potential compared to other types of mango. However, this species tends to be neglected and uncultivated. This study aimed to reveal the therapeutic potential in terms of the toxicity of the Mempelam. The study was conducted using the BSLT method with Artemia salina Leach. larvae as the test object. Concentration levels of methanol extracted fromMempelam leaves were 1000 ppm, 100 ppm, 10 ppm and 0 ppm. The LC50 result of the methanol extract of Mempelam leaves was obtained at 3.20 ppm. The result indicated that the methanol extracted from Mempelam leaves is highly toxic and has potential as an anticancer. In addition, toxicity of Mempelam leaves is higher than that of common cultivated mangoes. Thus, apparently it is promising to develop Mempelam as an alternative anticancer with less side effects.