Abstract:
Hyperpigmentation is a disorder of skin pigment that commonly occurs due to an
increase in the process of melanogenesis, which causes dark skin discoloration.
Pyrazoline and pyrazole are compounds of the azole group with a five-ring
heterocyclic structure that has various bioactivities. In this study, pyrazoline and
pyrazole compounds derived from 4-chloroacetophenone and 3,4-
dimethoxybenzaldehyde have been successfully synthesized through cyclic
condensation reactions and oxidative aromatization. The yield of the synthesis of
pyrazoline and pyrazole compounds was 45.31% and 18.37%, respectively. The
synthesis results were identified by UV, FTIR, NMR, and HRMS spectroscopy.
The target compound was tested for its bioactivity as a tyrosinase inhibitor through
molecular docking. Molecular docking was carried out to determine the affinity and
interaction of active ligands with target proteins, validation of the docking and
docking methods of ligands and target proteins. The visualization results show that
the interaction of the target compound has good activity than the positive control,
namely kojic acid.
