Abstract:
Curcumin is a compound diferuloylmethane and the related compoud are bioactive
phytochemical compounds that are generally isolated from the rhizome of Curcuma
Longa. L ( Tumeric ). Curcumin analogue compounds are compounds that have the
same or even better pharmalogical propeties when compared to curcumin compounds.
The asymmetric curcumin analogue 1-Benzyl-3-((E)-4-Chlorobenzyliden)-5-((E)-3-
Methoxybenzyliden-Piperidine-4-On was synthesized by the One-Pot method through
the Claisen schmidt reaction using base catalyst. The purity of the asymmetric
curcumin analogue compound was determined by TLC test, melting point
measurement and HPLC analysis. The structure of the synthesized compound was
obtained from UV, FTIR, 1H-NMR and HRMS spectroscopy studies. In the synthesis
of asymmetric curcumin analogue compounds, the yield was 4,77 % and the toxicity
test of these compounds using the Brine Shrimp Lethality Test (BSLT) method, the
LC50 value obtained was 6,83 μg/ml. Based on these result it can be concluded that
the asymmetric curcumin analogue 1-Benzyl-3-((E)-4-Chlorobenzyliden)-5-((E)-3-
Methoxybenzyliden-Piperidine-4-On is toxic.
