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SINTESIS DAN UJI TOKSISITAS SENYAWA 5-(4-BROMOFENIL)-3- (NAFTALEN-2-IL)-1-FENIL-1H-PIRAZOL

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dc.contributor.author Marcahesi, Neci
dc.date.accessioned 2021-08-24T02:55:14Z
dc.date.available 2021-08-24T02:55:14Z
dc.date.issued 2020-10
dc.identifier.other wahyu sari yeni
dc.identifier.uri https://repository.unri.ac.id/handle/123456789/10132
dc.description.abstract Pyrazole is a five rings of heterocyclic compounds with three carbon atoms and two nitrogen atoms in a position that adjacent each other and it has two endocyclic double bonds. Pyrazole has a pharmacological effect on humans and this compound as an important compound in the development of new drugs, one of which is an anticancer drug. Hence, in this study, the synthesis of pyrazole 5-(4-bromofenil)-3-(naftalen-2-il)- 1-fenil-1H-pirazol (PZL-4Br) via oxidative aromatization reaction from pyrazoline 5-(4- bromofenil)-3-(naftalen-2-il)-1-fenil-4,5-dihidro-1H-pirazol (PF-4Br-AN2) with glacial acetic acid. Synthesis of the PZL-4Br compound was used the reflux at 80⁰C. The purity of the compound was determined by using TLC, melting point and HPLC analysis. The structure of the synthesized compound was confirmed by UV, FTIR spectroscopic analysis. The toxicity of PZL-4Br compound was evaluated by Brine Shrimp Lethality Test (BSLT) method with shrimp larvae (Artemia salina Leach). PZL- 4Br compound successfully synthesized with 43,96% yield, LC50 = 3435,5 μg/mL which indicates that the compound PZL-4Br is non-toxic. en_US
dc.description.provenance Submitted by wahyu sari yeni (ayoe32@ymail.com) on 2021-08-24T02:55:14Z No. of bitstreams: 1 Neci Marcahesi_compressed.pdf: 172398 bytes, checksum: ac7f26e3834c39710572aad59cdc1715 (MD5) en
dc.description.provenance Made available in DSpace on 2021-08-24T02:55:14Z (GMT). No. of bitstreams: 1 Neci Marcahesi_compressed.pdf: 172398 bytes, checksum: ac7f26e3834c39710572aad59cdc1715 (MD5) Previous issue date: 2020-10 en
dc.description.sponsorship Dosen Bidang Kimia Organik Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Riau en_US
dc.language.iso en en_US
dc.subject BSLT (Brine Shrimp Lethality Test) en_US
dc.subject pyrazole en_US
dc.subject synthesis en_US
dc.title SINTESIS DAN UJI TOKSISITAS SENYAWA 5-(4-BROMOFENIL)-3- (NAFTALEN-2-IL)-1-FENIL-1H-PIRAZOL en_US
dc.type Article en_US
dc.contributor.supervisor Jasril, Jasril


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