Abstract:
Pyrazoline is a five-ring hetercyclic compound with two nitrogen atoms close in its
rings and has more than one endocyclic double bond. The availability of pyrazoline in
nature in small amounts, but has a good biological activity in treating various diseases
including as an anticancer or antidiabetic. This study aims to synthesize and confirm the
activity of pyrazoline compunds. Pyrazoline compound 3-(4-chlorophenyl)-5-(3-
methoxyphenyl)-1-phenyl-4,5-dihydro pirazol synthesized by one-pot reaction of three
components between 3-methoxybenzaldehyde, 4-chloroacetophenone and
phenylhydrazine with a base catalyst strong (NaOH), using the microwave irradiation
method. The compound showed a sufficient yield of 65.68% and the structure of the
pyrazoline compound was characterized using UV, FTIR, and 1H-NMR spectroscopy.
The PF-4Cl-3OMe pyrazoline compound has been docked using the Molecular
Operating Environment (MOE) program as an inhibitor of breast cancer and
doxorubicin as a standard. The PF-4C-3OMe pyrazoline compound showed an affinity
value of -7.2 kcal / mol higher than the doxorubicin standard of -10.4 kcal / mol and
there was an interaction in the form of hydrogen bonds between the ligand and one of
the active sites of the enzyme. These result indicate that the PF-4Cl-3OMe pyrazoline
compound has potential as an inhibitor of breast cancer
