Browsing by Author "Jasril, Jasril"
Now showing 1 - 20 of 28
Results Per Page
Sort Options
Item SINTESIS 5-(2-FLUOROFENIL)-3-(2-HIDROKSINAFTALEN-1-IL)- 1-FENIL-4,5-DIHIDRO-1H-PIRAZOL(Elfitra, 2022-11) Maulia, Nela Dwi; Jasril, JasrilPyrazoline is a five-membered heterocyclic compound with three carbon atoms and two adjacent nitrogen atoms within the ring. Pyrazoline 5-(2-fluorophenyl)-3-(2-hydroxy naphthalen-1-yl)-1-phenyl-4,5-dihydro-1H-pyrazole (PR-NH2-2F) had successfully synthesized by using two-steps, the first step of producing chalcone by reacting an aldehyde and a ketone involves the aldol condensation reaction, then producing pyrazoline by cyclization reaction between chalcone and phenylhydrazine. Synthesis of the pyrazoline by using monowave, at a temperature of 800C for 2 hours. The yield of the synthesis PR-NH2-2F compound was 52,35%. The purity of the compound was determined using TLC, melting point, and HPLC. The structure of synthesized compound was confirmed by ultraviolet (UV) and fourier transform infra-red (FTIR) spectroscopy data analysis.Item SINTESIS 5-(2-METOKSIFENIL)-3-(2-HIDROKSINAFTALEN-1-IL)- 1-FENIL-4,5 DIHIDRO-1H-PIRAZOL(Elfitra, 2022-11) Ramadani, Nuraini; Jasril, JasrilPyrazoline is five-ring heterocyclic compounds composed of three carbon atoms and two nitrogen atoms that are close together. The aim of this study was to synthesize naphthalene core pyrazoline compounds with hydroxy and methoxyphenyl groups on the pyrazoline ring. The compound 5-(2-methoxyphenyl)-3-(2-hydroxynaphthalen-1-yl)-1- phenyl-4,5-dihydro-1H-pyrazole (PRZ-2OCH3) was synthesized through two reaction steps. The first step is the reaction of 2-hydroxy-1-acetylnaphthalene and 2-methoxy benzaldehyde with NaOH 3N catalyst to give the compound 3-(2-methoxyphenyl)-1-(2- hydroxynaphthalen-1-yl)-2-propen-1-on. Produces a yield of 90.8%. Further, this chalcone was reacted with phenylhydrazine over a KOH 3N catalyst to give a yield of 72%. The target pyrazoline compounds were tested by TLC, melting point and HPLC analyses. Compounds were analyzed by UV-Vis spectrophotometer and FTIRItem SINTESIS DAN ANALISIS SENYAWA PIRAZOLIN 5-(4 -METOKSIFENIL)-3-(NAFTALEN-2-IL)-1-TOSYL-4,5-DIHIDRO-1H -PIRAZOL(Elfitra, 2022-11) Friska, Nanda Nabila; Jasril, JasrilPyrazoline is a five ring heterocyclic compound containing two adjacent nitrogen atoms and one endocylic double bond. Pyrazoline 5-(4-methoxyphenyl)-3-(naphthalene-2-yl)- 1-tosyl-4,5-dihydro-1H-pyrazole (PZN-2NFT-4TSH) had synthesized through the cyclization of the chalcone 3-(4-methoxyphenyl)-1-(naphthalen-2-yl)-2-propen-1-one with p-toluenesulfonyl hydrazine. The method used is stirring at 70-80oC assisted with hydrochloric acid as catalyst to produce white crystals with yield 47,33%. The purity of the compound was determined using TLC, melting point, and HPLC. The structure of synthesized compound was confirmed by ultraviolet (UV) and fourier transform infrared (FTIR) spectroscopy data analysis.Item SINTESIS DAN STUDI IN SILICO SENYAWA PIRAZOLIN 2-(5-(3- BROMOFENIL)-1-FENIL-4,5-DIHIDRO-1H-PIRAZOL-3- IL)NAFTALEN-1-OL) SEBAGAI KANDIDAT ANTIKANKER PAYUDARA(Elfitra, 2023-09) Anakri, Yasendi; Jasril, JasrilPyrazoline is a secondary metabolic compound containing five circular heterocyclic structures, comprising three carbon atoms and two nitrogen atoms positioned closely to each other. Due to its high toxicity, Pyrazoline exhibits diverse bioactivities, including antitumor and anticancer properties. Pyrazoline (2-(5-3-bromophenyl)-1-phenyl-4,5- dihydro-1H-pyrazole-3-yl)naphtalene-1-ol) has been successfully synthesized through several phases of reaction. The first phase involves the formation of chalcone 3-(3- bromophenyl)-1-(1-hydroxynaphthalene-2-yl)-2-propen-1-one by reacting the compound 1-hydroxy-2-acetylnaphthalene with 3-bromobenzaldehyde using the microwave irradiation method. Chalcone was synthesized using Claisen-Schmidt condensation reactions, resulting in a yield of 85.86%. In the subsequent step, chalcone was reacted with phenylhydrazine, leading to the desired compound in the presence of a sodium hydroxide catalyst. The synthesis of the target compound employed stirring and heating with seal tube, yielding 40.18%. The purification of the Pyrazoline compound was achieved through recrystallization. Its purity was assessed using TLC test, melting point determination, and HPLC analysis. Furthermore, the confirmation of its structure was based on spectroscopic data from UV, FTIR and LCMS. The molecular docking of PF-NH1-3Br against Estrogen α receptors revealed a free bond energy (ΔGbind) of -9,5 kcal/mol.Item SINTESIS DAN STUDI IN SILICO SENYAWA PIRAZOLIN 2-(5-4- KLOROFENIL)-1-FENIL-4,5-DIHIDRO-1H-PIRAZOL-3-IL)NAFTALEN- 1-OL SEBAGAI KANDIDAT ANTIKANKER PAYUDARA(Elfitra, 2023-09) Rosa, Nadia Verza; Jasril, JasrilPyrazoline is a pentacyclic heterocyclic compound having two adjacent nitrogen atoms and an endocyclic double bond. Pyrazoline is known to have various biological activities, one of which is anticancer. Pyrazoline 2-(5-4-chlorophenyl)-1-phenyl-4,5- dihydro-1H-pyrazol-3-yl)naphthalene-1-ol has been successfully synthesized through two stages of reaction. The first step begins with the formation of chalcone 3-(4- chlorophryl)1-(1-hydroxynaphthalene-2-yl)-2-propen-1-one by reacting 1-hydroxy-2- acetylnaphthalene and 4-chlorobenzaldehyde via Claisen-Schmidt condensation with a yield of 54%. The second stage was followed by reacting the synthesized chalcone compound with phenyl hydrazine using sodium hydroxide catalyst (pellets). The target compound synthesis method is heating a thick glass tube at a temperature of 70-80oC with a yield of 82%. The purity of the target compound was determined using Thin Layer Chromatography (TLC), melting point, and High Performance Liquid Chromatography (HPLC) analysis, then the chemical structure was confirmed through Ultraviolet (UV) spectroscopy, Fourier Transform Infra Red (FTIR), and Liquid Chromatography Mass Spectrometry (LC-MS) analysis. The results of molecular docking of PF-NH1-4Cl compound against α estrogen receptors have a binding free energy (ΔGbind) value of -9.3 kcal/mol and inhibition constant (Ki) = 1.49 nM.Item SINTESIS DAN STUDI MOLECULAR DOCKING SENYAWA 5-(2-2-(MORFOLIN-4-IL)ETOKSI)FENIL- 3-(NAFTALEN-2-IL)-1-FENIL-4,5-1H-PIRAZOL SEBAGAI KANDIDAT OBAT ANTIKANKER PAYUDARA(Elfitra, 2023-09) Karim, Muhammad Abdul; Jasril, JasrilPyrazoline is a five-membered heterocyclic compound containing two adjacent nitrogen atoms and an endocyclic double bond. This compound is a secondary metabolites, which exhibits diverse bioactivities, such as antibacterial, anti-inflammatory, antiviral, antitumor, anticancer, etc. Due to its limited availability in nature, this compound was imperative to be synthesized for the development of novel pharmaceuticals. A pyrazoline derivatives substituted with naphthalene and phenoxyethyl morpholine moiety with named as PRZ-2NFT-2OM was successfully synthesized in three-step of the reaction process. The initial stage involved the formation of chalcone (3) via the Claisen-Schmidt condensation reaction. The subsequent stage encompassed the formation of pyrazoline (5) through the cyclization reaction. The final stage entailed the fomation of PRZ-2NFT-2OM through O-alkylation of morpholine substituent, with yields of 31%, 74%, and 51%, respectively. The purity analysis of each synthesized compound was conducted using techniques such as thin-layer chromatography (TLC), determination of melting points, and high-performance liquid chromatography (HPLC). Based on spectroscopy data of UV, FTIR and LC-MS, the PRZ-2NFT-2OM compound was confirmed to match the intended structure. The PRZ-2NFT-2OM compound showed remarkable efficacy in in-silico bioactivity analysis through the molecular docking method as an inhibitor of alpha-estrogen protein (ER-α). It exhibited more potent values for binding free energy (ΔGbind) and inhibition constant (Ki) than its positive control which the values were -10.5 kcal/mol and 0.0198 μM for PRZ-2NFT- 2OM, whereas they were -9.5 kcal/mol and 1.27 μM for 4-hydroxytamoxifen.Item SINTESIS DAN STUDI MOLECULAR DOCKING SENYAWA KALKON 1- (NAFTALEN-2-IL)-PROP-2-EN-1-ON-3-(4-(2- MORFOLINETOKSI)FENIL) SEBAGAI KANDIDAT OBAT ANTIKANKER PAYUDARA(Elfitra, 2023-09) Simanjuntak, Jan Stepfely; Jasril, JasrilChalcone 1-(naphthalene-2-yl)-prop-2-en-1-on-3-(4-(2-morpholinetoxy)phenyl) (CLN- 2NFT-4OM) had been successfully synthesized via the Claisen-Schmidt reaction and followed by O-alkylation. The morpholine substituted chalcone compound was synthesized by stirring and heating at a temperature of 60-70°C for 14 hours and purified by recrystallization to produce a pale white crystalline solid with a yield of 63.74%. The structure of the target synthesis compound was analyzed and confirmed through UV, FTIR, LCMS, 1H-NMR, and 13C- NMR. The in silico test was carried out on CLN-2NFT- 4OM (5) as a breast anticancer agent through molecular docking of the estrogen receptor α (PDB ID:8DVB) with a positive control, namely 4-hydroxytamoxifen (4OHT). The results of the anticancer activity of CLN-2NFT-4OM and the positive control respectively through molecular docking analysis showed quite good inhibition of the estrogen receptor α by showing binding free energy (ΔGbind) data and an inhibition constant of -9.4 kcal/mol and 1.26 μM and -9.3 kcal/mol and 1.27 μM. These results are close enough between the target compound and the positive control indicating that the compound chalcone CLN- 2NFT-4OM has the potential to act as an inhibitor of estrogen receptor α which triggers as a cause of breast cancer.Item SINTESIS DAN UJI TOKSISITAS ANALOG 5-(3-FLUOROFENIL)-3-(NAFTALEN-2-IL)-1-FENIL- 1H-PIRAZOL(2021-01) Nurhayati, Asda; Jasril, JasrilPyrazole is an important group of five circular heterocyclic compounds containing two adjacent nitrogen atoms. Pyrazole compounds also have two endocyclic double bonds which is known to have diverse interesting biological activities such as, anticancer, antitumor and antioxidant. In this study, the pyrazole analogue 5-(3-fluorophenyl)-3- (naphthalene-2-yl)-1-phenyl-1H-pyrazole (PZL 2N-3F) was successfully synthesized through the synthesis of one-pot cyclization of pyrazoline which was then continued. By oxidative aromatization reaction of pyrazoline 5-(4-fluorophenyl)-3-(naphthalene2-yl)- 1-phenyl-4,5-dihydro-1H-pyrazole with glacial acetic acid under reflux for 42 hours. The purity of the synthesized compound was determined using the TLC, melting point and HPLC analysis. Structure identification was carried out through spectroscopic analysis of UV and FTIR. The yield obtained from the synthesis of PZL 2N-3F compound was 14.8%. The toxicity of pyrazole compounds was determined by the BSLT method using shrimp Larvae (Artemia salina Leach). The results of the BSLT for the PZL 2N-3F compound were non-toxic with an LC50 value of = 606.7 μg/mL.Item SINTESIS DAN UJI TOKSISITAS ANALOG PIRAZOL 5-(2-FLUOROFENIL)-3-(NAFTALEN-1-IL)-1-FENIL-1H-PIRAZOL(wahyu sari yeni, 2019-04-23) Ulhukmi, Nisa; Jasril, JasrilPyrazole is five ring heterocyclic compounds with two adjacent nitrogen atoms and it have two endocyclic double bonds which is known to have diverse biological activities such as anti-inflammatory, analgesic, antibacterial, antimalarial, antioxidant, and anticancer. Pirazol analogue 5-(2-fluorofenil)-3-(naftalen-1-il)-1-fenil-1H-pirazol (PZL-2F) was synthesized via oxidative aromatization reaction of pyrazoline 5-(2-fluorofenil)-3-(naftalen-1-il)-1-fenil-4,5-dihidro-1H-pirazolin (PF CN1-2F) with glacial acetic acid. Synthesis of the pyrazole compound used the reflux at 85⁰C. The purity of the compound is determined by using TLC, melting point and HPLC analysis. The structure of the synthesized compound was confirmed by UV, FTIR, and GC-MS spectroscopic analysis. The yield of the synthesis PZL-2F compound was 57.7%. The toxicity of pyrazol was evaluated by Brine Shrimp Lethality Test (BSLT) method with shrimp larvae (Artemia salina Leach). Pyrazole PZL-2F had high toxicity with LC50 = 49,07 μg/mL.Item SINTESIS DAN UJI TOKSISITAS ANALOG PIRAZOL 5-(4-FLUOROFENIL)-3-(NAFTALEN-2-IL)- 1-FENIL-1H-PIRAZOL(2020-10) Astuti, Rina; Jasril, JasrilPyrazole is five ring heterocyclic compounds with two adjacent nitrogen atoms and it have two endocyclic double bonds which is known to have diverse biological activities such as anti-inflammatory, analgesic, antibacterial, antimalaria, antioxidant, and anticancer. Pyrazole analogue 5-(4-fluorophenyl)-3-(naphthalen-2-yl)-1-phenyl-1Hpyrazole (PZL-4F-AN2) was successfully synthesized through synthesis of one-pot cyclization of pyrazoline which was then followed by oxidative aromatization reaction of pyrazoline 5-(4-fluorophenyl)-3-(naphthalen-2-yl)-1-phenyl-4,5-dihydro-1Hpyrazole with glacial acetic acid by refluxing the mixture for 36 hours in the oil bath at 85oC. The purity of the compound was determined by using TLC, melting point and HPLC analysis. The structure was confirmed using UV and FTIR spectroscopy analysis. The yield of the synthesis PZL-4F-AN2 compound was 18.29%. The toxicity of pyrazole was evaluated by Brine Shrimp Lethality Test (BSLT) method with shrimp larvae (Artemia salina Leach). Pyrazole PZL-4F-AN2 had high toxicity with LC50 = 43.07 μg/mL.Item SINTESIS DAN UJI TOKSISITAS HIDRAZON (E)-N’-((E)-3-(4- METOKSIFENIL)-1-(NAFTALEN-1-IL)ALLILIDEN)-4- METILBENZENSULFONOHIDRAZID(Elfitra, 2022-11) Rahmawati, Siti; Jasril, JasrilHydrazone is an imine-derived compound that has various biological activities, such as anticancer, antimalarial, antimicrobial, and antioxidant,. Hydrazone compound (E)-N'- ((E)-3-(4-methoxyphenyl)-1-(naphthalen-1-il)alliliden)-4-methylbenzensulfonohidrazid (HDZ-1-NFT-4-TSH) has been successfully synthesized. Begins with the formation of chalcone (E)-3-(4-methoxyphenyl)-1-(naphtalene-1-yl)-prop-2-en-1-one by reacting 1-acetylnaphtalene and 4-methoxybenzaldhyde with KOH 3N as catalyst then produced yield 29.70%. The next step was reacted chalcone and p-toluensulfonyl hydrazine with HCl 3N as catalyst then produced yield 77.87%. The hydrazone compound was tested with TLC test, melting point and HPLC analysis. The compound was analyzed by UV-Vis and FTIR spectrophotometer. The toxicity of the compound was evaluated by BSLT (brine shrimp lethality test) method using Artemia salina Leach larvae. The test results showed that the hydrazone compound was non-toxic with LC50 value of 251,18 μg/mL.Item SINTESIS DAN UJI TOKSISITAS PIRAZOLIN 5-(4-METOKSIFENIL)-3-(NAFTALEN-2-IL)-N-FENIL -4,5-DIHIDRO-1H-PIRAZOL-1-KARBOTIAMIDA(Elfitra, 2022-11) Putri, Sofia Rahmawati; Jasril, JasrilPyrazoline is heterocycles compound that has various biological activities such as anticancer. Pyrazoline 5-(4-methoxyphenyl)-3-(naphthalen-2-yl)-N-phenyl-4,5-dihydro- 1H-pyrazole-1-carbothioamide (PR-2NFT-4FTS) had successfully synthesized by the formation of chalcone 3-(4-methoxyphenyl)-1-(naphthalen-2-yl)-2-propen-1-one by reacting 2-acetylnaphthalene compound with 4-methoxybenzaldehide. Chalcone was reacted with 4-phenilthiosemicarbazide to produce target compound used hydrochloric acid as catalyst. The purity of the compound was determined using TLC, melting point, and HPLC. The structure of synthesized compound was confirmed by ultraviolet (UV) and fourier transform infra-red (FTIR) spectroscopy data analysis. The yield of the synthesis PR-2NFT-4FTS compound was 35.97%. The toxicity of PR-2NFT-4FTS compound was evaluated by brine shrimp lethality test (BSLT) method with shrimp larvae Artemia salina Leach. The result of the test showed PR-2NFT-4FTS compound is not toxic with LC50 > 1000 μg/mL.Item SINTESIS DAN UJI TOKSISITAS SENYAWA (1-(NAFTALEN-2-IL) ETILIDEN)HIDRAZIN(2021-03) Septiani, Vivin; Jasril, JasrilHydrazone is an organic compound that has a basic structure (R1R2C=N-NR3R4). Azomethine (-NHN=CH) is the active group of the hydrazone compound, which makes this compound has a variety biological activities. In this research, the synthesis of the hydrazone compound (1-(naphtalene-2-il)ethyliden)hydrazine (IHK-AN2) obtained from the condensation reaction between 2-acetylnaphtalene and hydrazine hydrate catalyzed by acetic acid. The compound was synthesized using microwave irradiation method with 180 watt. The purity of the compound was determined by TLC, melting point measurement and HPLC analysis. The compound was analyzed by UV and FTIR spectrophotometer. Synthesis of hydrazone in this research was concluded with a yield 85,86%. The toxicity of the IHK-AN2 compound was evaluated by BSLT method. LC50 value of the compound was >1000 μg/mL. From the data above was concluded that the IHK-AN2 compound was not toxic.Item SINTESIS DAN UJI TOKSISITAS SENYAWA 1,2-BIS(NAFTALEN- 1-ILMETILEN)HIDRAZIN(2020-08) Juwiyatri, Elda; Jasril, JasrilHydrazone is a versatile organic compound that has a basic structure (R1R2C=N-NR3R4). The active center of hydrazone are carbon and nitrogen atoms. The active group of the hydrazone compound is azomethine (-NHN=CH-), which makes this compound the most important in the development of new medicines. In this research, the synthesis of the compound hydrazine 1,2- bis(naphthalene-1-ilmethylene)hydrazine (IHA-ND1) obtained from the condensation reaction between the 1-naphthaldehyde and hydrazine hydrate catalyzed by acetic acid. This compound was synthesized using a microwave irradiation method with 180 Watt. The purity of the compound was determined by TLC and melting point measurement. The structure of the synthesized compound was confirmed through spectroscopic UV and FTIR analysis. The results of this research were the IHA-ND1 compound successfully synthesized with a 54,87% yield. The bioactivity of the IHA-ND1 compound was evaluated its toxicity properties by the BSLT method using shrimp larvae (Arthemia salina Leach). LC50 value of compounds IHAND1 is 47,20 μg/mL. It can be concluded that the compound IHA-ND1 is toxic, and further pharmacological tests can be carried outItem SINTESIS DAN UJI TOKSISITAS SENYAWA 1-(NAFTALEN-1- ILMETILEN)-2-FENILHIDRAZIN(2020-10) Fauza, Sarfatika Nurul; Jasril, JasrilHydrazone is an organic compound that has a variety of biological activities such as antioxidant and anticancer. The active group of hydrazone compound the azomethine group (-NHN=CH-) makes this compound as an important compound in the development of new drugs. Hence, in this study, the synthesis of hydrazone 1-(naphthalene-1-ylmetilen)-2-phenylhydrazine (IFA-ND1) was obtained from the condensation reaction between 1-naphthalene and phenylhydrazine catalyzed by acetic acid. This compound was synthesized compound by microwave irradiation method at 180 Watt. The purity of the compound is determined by using thin layer chromatography and melting point. The structure of the synthesized compound was characterized by the spectrum of UV and FTIR. The bioactivity of the IFA-ND1 compound was evaluated with its toxicity properties by BSLT method with a value of LC50 = 1.455 μg/mL. This suggests that the IFA-ND1 compound is a potential compound with toxic propertiesItem SINTESIS DAN UJI TOKSISITAS SENYAWA 5-(3-KLOROFENIL)-3-(NAFTALEN-2-IL)-1-FENIL-1H-PIRAZOL(2020-10) Putri, Wahyuni Eka; Jasril, JasrilPyrazole is a 5 ring heterocyclic compound consisting of three carbon atoms and two nitrogen atoms in adjacent positions. In this study, the pyrazole analogue 5-(3-chlorophenyl)-3-(naphthalen-2-il)-1-phenyl-1H-pyrazole (PZL-2N-3Cl) was successfully synthesized from pyrazoline 5-(3-chlorophenyl)-3-(naphthalen-2-il)-1- phenyl-4,5-dihydro-1H-pyrazoline (PF-CN2-3Cl) with glacial acetic acid via oxidative aromatization reaction using reflux for 24 hours. The purity of the synthesized compound was determined using TLC and melting point. The structure of the synthesized compound was confirmed by UV and FTIR spectroscopic analysis. The yield obtained from the synthesis of the PZL-2N-3Cl compound was 30,12%. The toxicity test of pyrazole compounds was determined by the BSLT method using shrimp larvae (Artemia salina Leach). Pirazol PZL-2N-3Cl is non-toxic with an LC50 value of = 4.634,4 μg / mLItem SINTESIS DAN UJI TOKSISITAS SENYAWA 5-(4-BROMOFENIL)-3- (NAFTALEN-2-IL)-1-FENIL-1H-PIRAZOL(2020-10) Marcahesi, Neci; Jasril, JasrilPyrazole is a five rings of heterocyclic compounds with three carbon atoms and two nitrogen atoms in a position that adjacent each other and it has two endocyclic double bonds. Pyrazole has a pharmacological effect on humans and this compound as an important compound in the development of new drugs, one of which is an anticancer drug. Hence, in this study, the synthesis of pyrazole 5-(4-bromofenil)-3-(naftalen-2-il)- 1-fenil-1H-pirazol (PZL-4Br) via oxidative aromatization reaction from pyrazoline 5-(4- bromofenil)-3-(naftalen-2-il)-1-fenil-4,5-dihidro-1H-pirazol (PF-4Br-AN2) with glacial acetic acid. Synthesis of the PZL-4Br compound was used the reflux at 80⁰C. The purity of the compound was determined by using TLC, melting point and HPLC analysis. The structure of the synthesized compound was confirmed by UV, FTIR spectroscopic analysis. The toxicity of PZL-4Br compound was evaluated by Brine Shrimp Lethality Test (BSLT) method with shrimp larvae (Artemia salina Leach). PZL- 4Br compound successfully synthesized with 43,96% yield, LC50 = 3435,5 μg/mL which indicates that the compound PZL-4Br is non-toxic.Item SINTESIS DAN UJI TOKSISITAS SENYAWA 5-(4-FLOROFENIL)-3-(2- HIDROKSINAFTALEN-2-IL)-1-FENIL-4,5-DIHIDRO-1H-PIRAZOL(perpustakaan UR, 2021-10) Ningsih, Winda Ayu; Jasril, JasrilPyrazoline is a five-ring heterocyclic compound which has two nitrogen atoms close together in the ring and has only one endocyclic double bond. Pyrazoline analogue 5-(4-fluorophenyl) -3- (2-hydroxynaphthalene-2-yl) -1-phenyl-4,5-dihydro-1H-pyrazole (PF-NH2-4F) is synthesized by cyclization reaction of chalcone compounds 3-(4-fluorophenyl) -1- (2-hydroxy naphthalene -2-yl) -2- propen -1-one with phenyl hydrazine. Synthesis of the pyrazoline using monowave, at a temperature of 80oC for 2 hours. The purity of the compound was determined using TLC test, melting point measurement and HPLC analysis. The structure of the synthesized compound was confirmed by means of UV-Vis and FTIR. The yield resulting from the synthesis of the compound PF-NH2-4F was 47.42%. The activity test of pyrazoline compounds was determined by the BSLT method using shrimp larvae (Artemia salina Leach) which obtained an LC50 value of 7.88 μg/mL, which are considered to have moderate levels of toxicity due to their toxicity activity have LC50 values >1 μg/mL and <100 μg/mLItem SINTESIS DAN UJI TOKSISITAS SENYAWA 5-(4-FLUOROFENIL)-3-(1-HIDROKSINAFTALEN-2-IL)-1-FENIL-4,5-DIHIDRO-1HPIRAZOL(perpustakaan UR, 2021-10) Nadia, Airin; Jasril, JasrilPyrazoline is a five ring heterocyclic compounds that cointaining two nitrogen atoms in a close position with one double bond in the ring which is known to have various bioactivities such as an anti-oxidant, anti-cancer, anti-microbial, and anti-bacterial. The pyrazoline derivative 5-(4- fluoropheny)-3-(1-hydroxynaphthalene-2-yl)-1-phenyl-4,5-dihydro-1H-pyrazole (PF-NH1-4F) was synthesized by the cyclization reaction of chalcone 3-(4-fluorophenyl)-1-(1- hydroxynaphthalene-2-yl)-2-propen-1-one and phenyl hydrazine with NaOH (in methanol) as catalyst using monowave at 80°C for an hour. The chalcone was prepared by condensing 1- hydroxy-2-acetylnaphtalene and 4-fluorobenzaldehyde with NaOH as catalyst using microwave irradiation at 180 W about 17 minutes. The purity of the pyrazoline was analyzed using TLC, melting point, and HPLC. The yield of the synthesis of chalcone and pyrazoline compounds was 45% and 27,3%. The structure of the synthesized pyrazoline was comfirmed by UV, FTIR, and HRMS spectroscopy analysis. The toxicity of pyrazoline was evaluated by Brine Shrimp Lethality Test (BSLT) method. The result of the test showed that the pyrazoline PF-NH1-4F is highly toxic with LC50 value was 11,1 μg/mLItem SINTESIS DAN UJI TOKSISITAS SENYAWA 5-(4-KLOROFENIL)-3- (NAFTALEN-2-IL)-1-FENIL-1H-PIRAZOL DARI PIRAZOLIN(2020-08) Dewi, Gira Fitri; Jasril, JasrilPyrazole is a 5-ring heterocyclic compound which consist of 3 carbon atoms and 2 neighboring nitrogen atoms. This study was aimed to synthetized pyrazol compound and toxicity of the compound was determined by BSLT method. The pyrazole 5-(4- chlorophenyl)-3-(naphthalene-2-il)-phenyl-1H-pyrazole was synthesized through the oxidative aromatization reaction of pyrazolin compounds with glacial acetic acid. The synthesized compound was tested for purity using TLC, melting point and HPLC analysis. The structure of the synthesized compound was confirmed through UV spectroscopy and FTIR. The synthesis of pyrazole has the yield of 38,3%. Pyrazole was subjected to toxicity test through BSLT method using shrimp larvae (Artemia salina Leach). The pyrazole was toxic with LC50 value of 20,13 μg/mL.