SINTESIS DAN UJI TOKSISITAS ANALOG DARI TURUNAN KALKON (E)-3-(4-HIDROKSIFENIL)-1- (2-METOKSIFENIL)-PROP-2-EN-1-ONE
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Date
2019-08-15
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wahyu sari yeni
Abstract
Pyrazole is a important group of five ring heterocyclic alkaloid compounds containing two adjacent nitrogen atoms which have a diverse biological activities such as anti-inflammatory, analgesic, and antioxidant. Chalcone analogue of (E)-3-(4-hidroksifenil)-1-(2-metoksifenil)-prop-2en-1-one was synthesized via oxidative aromatization reaction with phenylhydrazine and catalyzed with glacial acetic acid. Chalcone was synthesized via microwave at 180 W and and pyrazoles were synthesized via reflux at 80oC. The purity of the compounds were determined by TLC, melting point and HPLC analysis. The structure of synthesized compounds were confirmed by UV, FTIR, NMR and HRMS spectroscopy studies. The toxicity of pyrazol was evaluated by Brine Shrimp Lethality Test (BSLT) method. Pyrazole PFC-4OH-2OMe considered toxicity as LC50= 165.95 μg/mL because the value of LC50 is less than 200 μg/mL
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Keywords
Alkaloid, Brine Shrimp Lethality Test, reflux, pyrazol, toxicity