SINTESIS DAN UJI TOKSISITAS ANALOG FLAVANON TERSUBSTITUSI HALOGEN
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Date
2015-03-31
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Abstract
Flavanones have been reported to possess many of interesting biological activities such
as antimicrobe, antitumor, antioxidance, antiinflammatory, antimalaria, anticancer, and
anti-HIV. In this research, a halogenated flavanone 2-(3-bromophenyl)chroman-4-one
was synthesized by cyclization of (E)-3-(3-bromophenyl)-1-(2-hydroxyphenyl)-2-
propen-1-one using sodium acetate as catalyst under microwave irradiation. The
compound showed a good yield, and then was characterized by UV, IR and 1H-NMR
spectroscopy. The toxicity activity of this compound was determined using Brine
Shrimp Lethality Test (BSLT) method against larvae Artemia salina Leach and showed
a good activity with LC50 = 0,457 μg/mL. The result indicated that this compound was
potential as anticancer.
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Keywords
hydroxychalcone, BSLT, toxicity, flavanone