SINTESISDANUJITOKSISITASSENYAWAKALKON TURUNAN4’–METILASETOFENON
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Date
2014-03-27
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Abstract
(E)-3-(4-chlorophenyl)-1-p-tolylprop-2-en-1-one has been synthesized from 4’-methylacetophenoneand4 chlorobenzaldehydeusingNaOH(5%) asacatalystby
Claisen Schmidt condensation in good yield.The product has been determined,interm
of its melting point,identified byKLT,then elutedwithUV-Vis,FT-IR,MS,and
1H-NMR.Chalcones compound toxicity test was done using Brine Shrimp LethalityTest
(BSLT)method against larvae Artemia salina Leach.LC50 value for compound(E)-3-
(4-chlorophenyl)-1-p-tolylprop-2-en-1-one is 2,81 µg/mL. The analog chalcone compound are positively potential as anti-cancer.
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BrineShrimpLethalityTest(BSLT), chalcone, toxicitytest.