SINTESIS DAN UJI TOKSISITAS SENYAWA 1,2-BIS(NAFTALEN- 1-ILMETILEN)HIDRAZIN
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Date
2020-08
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Abstract
Hydrazone is a versatile organic compound that has a basic structure (R1R2C=N-NR3R4). The
active center of hydrazone are carbon and nitrogen atoms. The active group of the hydrazone
compound is azomethine (-NHN=CH-), which makes this compound the most important in the
development of new medicines. In this research, the synthesis of the compound hydrazine 1,2-
bis(naphthalene-1-ilmethylene)hydrazine (IHA-ND1) obtained from the condensation reaction
between the 1-naphthaldehyde and hydrazine hydrate catalyzed by acetic acid. This compound
was synthesized using a microwave irradiation method with 180 Watt. The purity of the
compound was determined by TLC and melting point measurement. The structure of the
synthesized compound was confirmed through spectroscopic UV and FTIR analysis. The
results of this research were the IHA-ND1 compound successfully synthesized with a 54,87%
yield. The bioactivity of the IHA-ND1 compound was evaluated its toxicity properties by the
BSLT method using shrimp larvae (Arthemia salina Leach). LC50 value of compounds IHAND1
is 47,20 μg/mL. It can be concluded that the compound IHA-ND1 is toxic, and further
pharmacological tests can be carried out
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Keywords
azomethine, hydrazone, toxicity