Abstract:
Chalcone is one of secondary metabolites from flavonoids group that have been
reported to posses many biological activities such as antimicrobial, antitumor,
antioxidant, anti-inflammatory, antimalari and anticancer. Chalcone generally can be
synthesized by Claisen-Schmidt condensation from aldehide and ketone aromatic using
acid or base catalyst. Three hydroxy analogues chalcone i.e., (E)-3-(2-hidroksifenil)-1-
(2’-metoksifenil)prop-2-en-1-on, (E)-3-(3-hidroksifenil)-1-(2’-metoksifenil)prop-2-en-
1-on and (E)-3-(4-hidroksifenil)-1-(2’-metoksifenil)prop-2-en-1-on have been
synthesized under microwave irradiation by using pottasium hydroxide as catalyst. The
structure of those compounds were characterized based on the interpretation of
spectroscopic data included UV, FTIR, 1H-NMR and HRMS. Their toxicity activity
were determined by using the Brine Shrimp Lethality Test method againts larvae of
Artemia salina Leach and showed high activity with LC50 value was 66,59 μg/mL,
107,45 μg/mL and 449,44 μg/mL, respectivel. It indicated that chalcone analogues were
potential as anticancer
