SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG KURKUMIN DARI SIKLOHEKSANON DENGAN KLORO BENZALDEHID

Abstract

Curcumin is one of secondary metabolites of phenolic group which has been known to have biological activity such as anticancer, antioxidant, antidiabetic, and anti-inflammatory. Therefore, curcumin becomes model of target compounds that have various structure. In this research, curcumin analog compounds of cyclohexanones and chloro benzaldehyde were synthesized by using NaOH as a catalyst with Claisen-Schmidt condensation under microwave irradiation. The yield obtained for (2E,6E)-2,6-bis(4-chlorobenzylidene)cyclohexanone was 47.4 %. The identification of curcumin analog compound was analysed using UV, IR, 1H-NMR and MS. The toxicity test carried out by Brine Shrimps Lethality Test (BSLT) method againts Artemia salina Leach larva showed that LC50 was higher 200 ppm. Toxicity test result indicated showed that the compound synthesized was not toxic