SINTESIS DAN UJI TOKSISITAS SENYAWA ANALOG KURKUMIN DARI SIKLOPENTANON DENGAN TURUNAN BENZALDEHID

Abstract

The analogues compound of curcumin were reported to have many biological activities such as antioxidant, anti-inflammatory, anticancer, antiviral, antidiabetic, anticarcinogenic and antibacterial. Curcumin analog of (2E,5E)-2,5-bis(2-methoxybenzylidene)cyclopentanone (NK) has been successfully synthesized with yields 71,85%. The compound was resulted by aldol condensation reaction between cyclopentanone and benzylidene derivates under microwave irradiation using NaOH 8% as catalyst. The compound of curcumin analog structure was characterized based on the interpretation of spectroscopy UV, IR, 1H-NMR and MS. The compound was screened for toxicity activities against larvae of Artemia salina Leach through Brine Shrimp Lethality Test (BSLT) method and its LC50 was 2996,4015 μg/mL as nontoxic compound.