Abstract:
Four analogue curcumins (3b, 3e, 3h and 3i) have been synthesized from aldehyde and ketone by
using Claisen-Schmidt condensation under base condition. All the compounds have been
confirmed their structure by using UN, IR, 1HNMR and 13CNMR spectroscopy analysis.
Generally, all the compounds showed cytotoxicity activity with IC50 value 15 – 80 ppm against
murine leukemia (P-388) cell lines. The results showed that 3i could inhibit the highest P-388 cell
line growth percentage.
